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PepMetric Technologies Inc.
 


About PepMetric

PepMetric Technologies Inc. specializes in therapeutic and diagnostic peptide discovery. The company offers fast, accurate and economical peptide-based research services (peptide array [macroarray or microarray] and peptide synthesis) to academic and commercial customers.

Through many years of proteomic research, founders of the company have accumulated extensive peptide interaction libraries and developed sophisticated algorithms for identifying peptides interacting with target molecules.

PepMetric Technologies has several patents on therapeutic and diagnostic peptides for a variety of diseases.

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Technologies:

 

PepMetric provides not only high-quality custom peptide synthesis service, but also Peptide Array - based high-throughput products (Pep-Overlap, Pep-Scan, Pep-Optima, Pep-Hit, Pep-Phos, Pep-Lyse and Pep-Well) for life science researchers.

Peptide microarray or macroarray is a useful tools for epitope mapping, identification of domain motif of protein-protein interaction, optimization of peptide / substrate sequence, kinase/protease substrate specificity, peptide drug discovery & design, enzyme (kinase, phosphotase, protease) studies, etc (read more).

 

Discoveries:

PepMetric has successfully mapped all specific epitopes of SARS Corona Virus, and discovered several bioactive peptides, including a peptide inhibiting reverse transcriptase of HIV (a key enzyme for HIV replication), and a peptide preventing Tau aggregation (major pathogentic factor of Alzheimer's disease), etc. (Read more)

 




Other Useful Links:
Science
Nature
NBCI/PubMed
Peptide DataBank (1, 2, 3)
Protein DataBank (1, 2, 3, 4, 5)
Biology Protocol Online
Encyclopedia of Biology
Biotechniques Forum
Molecular Station
Biology Online

Publications:

Munoz Cdel C, Campbell W, Constantinescu I, Gyongyossy-Issa MI. Rational design of antithrombotic peptides to target the von Willebrand Factor (vWf) - GPIb integrin interaction. J Mol Model. 14(12):1191-202 (PubMed Link)

Fujita E., Farkas,I., Campbell, W., Okada, H. and Okada N. 2004. Inactivation of C5a Anaphlatoxin by a Peptide that is Complementary to a Region of C5a. J. Immunol. 172: 6382-6387. (PubMed Link)

Guo,J., Petric, M. Campbell W. McGeer A. and McGeer P. 2004. SARS Corona Virus Peptides Recognized by Antibodies in Sera of Convalescent Cases. Virology 324:251-256 (PubMed Link)

2006, Hilpert K, Elliott MR, Volkmer-Engert R, Henklein P, Donini O, Zhou Q, Winkler DF, Hancock RE. Sequence Requirements and an Optimization Strategy for Short Antimicrobial Peptides. Chem Biol. 13(10):1101-7 (PubMed Link)

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Pep-Overlap
Pep-Hit
Pep-Phos
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