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Pep-Hit

PepMetric has developed an unique algorithm for peptide design on principles of Complementary Hydropathy, Site Chain Interference/Steric Hindrance, α-Carbon Approach/Backbone Alignment, and Charge Transfer Capacity.

Taking advantage of this sophisticated algorithm for peptide design, the Pep-Hit plateform will generate a number of peptide candidates, based on their best fitness scores for a given aa sequence. Our experience shows peptides generated by Pep-Hit have a greater chance (>5~20 per 1000 peptide candidates) to bind to the target aa sequence.

Specifications and Applications:

• Target AA sequence can be as long as 20 amino acid residues
• Output of up to ~1000 peptide candidates or on customers demand
• High success rate: >5~20 peptides per 1000 candidates (bioactivity should be further evaluated by other tests)
• Peptide candidates can be synthesized on cellulose membrane for high-throughput screening at low cost.
• Useful for peptide drug research and development, inhibitor/activator discovery.
• Straightforward workflow (flowchart and chemicals)

Accomplishments:

• a peptide inhibtor targeting V3 loop of HIV reverse transcriptase
• a peptide interfering with vWF-GPIb interaction
• a peptide abolishing exflux function of multidrug ressitant protein P-GP in cancer cell lines
• a peptide complementary to procarboxypeptidase and inactivating the latter
• more...

Pricing:

• Fee for peptide design: $1,000
• Fee for peptide array: $1/amino acid residue (USD for overseas customers)
• Calculation of number of amino acid residues: for example, to make a peptide array of 1,000 12-mer peptide candidates, the number of total amino acid residues is 1,000×12=12,000.

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